'METHOD FOR THE PRODUCTION OF SELENIUM METHYLENE BLUE, RADIOACTIVE SELENIUM METHYLENE BLUE, ITS PRODUCTION AND USE IN PREPARATIONS FOR THE PREPARATION OF EPITHELIC BODY ADENOMAS'

摘要

1. Claims for the Contracting States : BE, CH, DE, FR, GB, IT, LI, NL, SE A process for the preparation of selenium methylene blue, which comprises reacting 3-bromo-N,N-dimethyl aniline in an anhydrous solvent with magnesium to yield 3-dimethylaminophenyl magnesium bromide, adding selenium to obtain 3-dimethyl-aminophenyl selenomagnesium bromide, hydrolyzing said compound by means of aqueous mineral acid to yield 3-dimethylamino-selenophenol, converting said compound by oxidation into bis-(3-dimethylaminophenyl)-diselenide and reacting said compound with 4-nitroso-N,N-dimethyl aniline or one of its salts in an aqueous solvent. 1. Claims for the Contracting State : AT A process for the preparation of selenium methylene blue, which comprises reacting 3-bromo-N,N-dimethyl aniline in an anhydrous solvent with magnesium to yield 3-dimethylaminophenyl magnesium bromide, adding selenium to obtain 3-dimethyl-aminophenyl selenomagnesium bromide, hydrolyzing said compound by means of aqueous mineral acid to yield 3-dimethylamino-selenophenol, converting said compound by oxidation into bis-(3-dimethylaminophenyl)-diselenide and reacting said compound with 4-nitroso-N,N-dimethyl aniline or one of its salts in an aqueous solvent.