4-Piperidinyl indole derivs. - with dopaminergic activity e.g. for treating Parkinsons disease and excessive prolactin secretion

摘要

Indole derivs. of formula (I), within the general scope of the parent patent, and their acid addn. salts are new. (X is methyl and Y is 3-piperidinyl (cpd. Ia) or 1-propyl-3-piperidinyl (Ib); or X is H and Y is 1-ethyl-3-piperidinyl (Ic) or 1-ethyl-1,2,5,6-tetrahydro-3-pyridinyl (Id)). Specificed salts are the hydrochloride of (Ia); the oxalate of (Ib); the neutral fumarate of (Ic) and the phosphate of (Id). (I) are useful as dopaminergic stimulants; some also have adrenergic and serotoninergic activities. They are useful for treating extrapyramidal neurological disorders (e.g. Parkinson's disease); excessive secretion of prolactin (e.g. hypogonadism); cerebral senescence; vertebrobasal insufficiency; arterial hypertension; peripheral circulator disorders; and arteriopathy of the legs. All cpds. were tolerated at doses of 60 mg or more per kg, intraperitoneally in mice, without any deaths.