1, 2, 3, 4, 4A, 9b - hexahydro - 4a - piperazinylmethyl - 4 - dibenzofuranones or 4 - dibenzofuranols substituted, and the application of international application no.

摘要

The present invention is dealing with compounds of the formula: IMAGE I and pharmaceutically acceptable salts thereof, in which R1, R2, R3 and R4 are identical or different and represent hydrogen, halogen, lower alkyl or alkoxy or trifluoromethyl; R5 represents hydrogen or lower alkyl, X represents hydrogen and Y represents hydroxy, or X and Y together represent oxygen and Ar represents an optionally substituted aromatic moiety, having potent anti-bronchoconstrictor properties.