PROCESS FOR OBTAINING CAPSULAR POLYOSIDES, CAPSULAR POLYOSIDES THUS OBTAINED AND THEIR APPLICATION TO THE PREPARATION OF VACCINES

摘要

THE PRESENT INVENTION IS A PROCESS FOR OBTAINING IMMUNOGENIC CAPSULAR POLYOSIDES FROM CAPSULATED BACTERIA CONTAINING THEM, CHARACTERIZED IN THAT BACTERIA CULTURE IS CARRIED OUT IN A SYNTHETIC OR SEMI-SYNTHETIC MEDIUM, AT THE END OF THE PHASE OF GROWTH OF THIS CULTURE WE SEPARATE THE MICROBIAL BODIES OF A SURNAGING PHASE, WE SUBMIT THIS SURNAGING PHASE TO A FILTRATION RETAINING THE MOLECULES OF A MOLECULAR MASS EQUAL OR SUPERIOR TO 100,000DALTONS, OBTAINING A RICH RETENTING PROTEINS, NUCLEIC ACIDS AND LIPIDS ARE ELIMINATED FROM THIS RETENTATE, OBTAINING A PURIFIED CAPSULAR POLYOSIDE.