PROCESS FOR THE PREPARATION OF RADIOISOTOPE COLLOIDAL LIGANDS FROM HUMAN SERUM ALBUMIN AND THEIR USE FOR THE PREPARATION OF RADIO-ACTIVE PRODUCTS FOR SCINTIGRAPHIC EXAMINATION

摘要

A COLLOIDAL SOLUTION OF HUMAN SERUM ALBUMIN IS PREPARED BY MIXING AQUEOUS SOLUTION OF THE SAME WITH A NON-IONIC SURFACTANT AND AN ACID SOLUTION OF A STAINLESS SALT, ADJUSTING THE pH FROM 3.5 TO 8.0 AND HEATING AT CONSTANT TEMPERATURE SITUATED BETWEEN 45 AND 100C, UNTIL COMPLETE HYDROLYSIS OF STAINLESS SALT AND DENATURING ALBUMIN; THE COLLOIDAL SOLUTION CAN ALSO BE LYOPHILIZED. BY TREATING THE SOLUTION OR PRODUCT LYOPHILIZED BY A TC-PERTECHNETATE SOLUTION, A COLLOIDAL PRODUCT IS OBTAINED FOR SCINTIGRAPHY OF THE RETICULO-ENDOTHELIAL SYSTEM OR LYMPATHIC SYSTEM. BY THE ONLY ADJUSTMENT OF AN APPROPRIATE PH, THE PROCESS SELECTIVELY OBTAINES COLLOIDS HAVING A PARTICULAR DIMENSION, FOR EXAMPLE, FROM 3.0 TO 0.2 OR FROM 0.2 TO 0.03 OR LESS 0.03mm.