Stable antacid suspension of aluminium and/or magnesium hydroxide(s) - prepd. by mixing powdered prod. with water, fragmenting and dispersing to give particle size of 5-10 microns

摘要

Process for the preparation of a stable suspension of aluminium hydroxide and/or magnesium hydroxide, as active antacid agent, by mixing the aluminium hydroxide and/or magnesium hydroxide in powder form with water and then mechanically fragmenting and dispersing the mixture, until the mean particle size is of the order of 5-10 microns. Used for treatment of gastric hyperactivity. The present invention provides a high concentration neutralising suspension, having a creamy consistency, which is suitable for oral administration and has particles of sufficiently small and homogeneous size to give a dispersion having an active total surface adequate for gastric purposes and has an alkalinising capacity which is constant and measurable. The neutralising capacity is at least four times that of comparable products prepared as gels and is superior to that of concentrated gels, thus allowing smaller amounts of product to be used.