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Formimidoyl A and B useful as semi-synthetic aminoglycosidic antibiotics
Formimidoyl A and B useful as semi-synthetic aminoglycosidic antibiotics
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机译:甲酰亚胺基甲和乙可用作半合成氨基糖苷类抗生素
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摘要
New, useful derivatives of istamycins A and B are provided, which are formimidoylistamycins A and B of formula (I) having a toxicity significantly lower than those of istamycins A and B with an antibacterial activity higher than that of fortimicin A and of the same level as those of istamycins A and B. These compounds may be prepared by reacting 1,2',6'-tri-N-protected istamycins A and B of formula (V) with an iminoether.
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