AGENT FOR TREATMENT OF EXCESSIVE LIPID PEROXIDE IN SERUM

摘要

PURPOSE:To provide the titled remedy containing a specific carboxylic acid, its salt, its lower alkyl ester or its lactone, as an active component. CONSTITUTION:The objective agent is obtained by using the carboxylic acid of formula I (R1 is H or methyl) or formula II (R2 is H or methyl; R3 is OH or methoxy), its salt, its lower alkyl ester or its lactone, as an active component. The compound of formula I or formula II can be prepared by the microbial enzymatic hydroxidation of MB-530B or ML-236B (Japanese Patent Laid-open No. 56-110618) or their derivatives. Dose: 0.05-25mg/kg daily for M-4 compound, 0.1-50mg/kg daily for M-4' compound, iso-M-4 compound, etc., 0.05-25mg/kg daily for 3-hydroxy-MB-530B compound, etc., and 0.05-50mg/kg daily for 6- methoxy-iso-ML-236B compound.