A process for the preparation of a sustained release formulation containing dipyridamole which comprises forming a plurality of spherodial cores containing dipyridamole or a salt thereof and a physiologically compatible acid substance in a ratio of at least 1 equivalent of acid substance to 1 mol of dipyridamole or a salt thereof and coating said cores with a coating whereby spheroidal particles are obtained the siad coating comprising from 100 to 50% by weight of acid-insoluble lacquer soluble in intestinal juices and from 0 to 50 percentage by weight of lacquier insoluble in gastrie and intestinal juices comprises ethyl cellulose, the weight of ethyl cellulose present does and exceed 14% of the total weight of the coating.
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