substituted phenylalkyl - (piperazinyl or homopiperazinyl) - alkylthioler and thiocarbamates, salts thereof, and method for their manufacture

摘要

Compounds of the formula CHEM wherein R is hydrogen or -@-NH-A; A is alkyl of 1 to 8 carbon atoms; cycloalkyl of 3 to 7 carbon atoms; or unsubstituted or mono-, di- or tri-substituted phenyl, where the substituents are each alkyl of 1 to 4 carbon atoms, halogen, trihalomethyl, alkoxy of 1 to 3 carbon atoms, carboxylic acyl of 1 to 3 carbon atoms, carboxyl, (alkoxy of 1 to 3 carbon atoms)carbonyl, nitro, cyano or di(alkyl of 1 to 3 carbon atoms)amino; R1, R2 and R3, which may be identical to or different from each other, are each hydrogen, halogen, allryl of 1 to 4 carbon atoms, trihalomethyl, nitro, cyano, di(alkyl of 1 to 4 carbon atoms)amino, (alkoxy of 1 to 4 carbon atoms)carbonyl, alkoxy of 1 to 4 carbon atoms or hydroxyl; R4 and R5 which may be identical to or different from each other, are each hydrogen, alkyl of 1 to 4 carbon atoms or phenyl; R6 R7, R8 and R9, which may be identical to or different from each other, are each hydrogen or methyl, Y is -CH2- or -CH2-CH2; j is 0 or 1; k and m are each integers of 0 to 3, their sum being no more than 6 must be 0 when j is 1; n is an integer of 2 to 4, with the proviso that n must be 3 or 4 when R1 is hydrogen or 2-methyl, R2, R3, R4, R5, R6, R7, R8, R9, and R are hydrogen and j, k and m are 0 and Y is CH2-; and non-toxic, pharmaceutically acceptable acid addition salts thereof. The compounds as well as their salts are useful for the treatment of immunological, inflammatory and allergic disorders.