首页> 外国专利> foerfarande foer framstaellning av farmaceutiskt anvaendbara inklusionskomplexer av prostacyklin och prostacyklin - c1 - 4 - estrar med beta cyklodextrin

foerfarande foer framstaellning av farmaceutiskt anvaendbara inklusionskomplexer av prostacyklin och prostacyklin - c1 - 4 - estrar med beta cyklodextrin

机译:前列环素和前列环素-c1-4酯与β-环糊精的可药用包合配合物的制备方法

摘要

Prostacyclin and prostacyclin derivatives form inclusion complexes with cyclodextrins. The complexes may be prepared by contacting an aqueous solution of the cyclodextrin with prostacyclin or a derivative thereof, preferably in organic solvent solution. The inclusion complexes have an improved stability, especially in aqueous solution, compared to the uncomplexed compounds and are extremely potent in inhibiting thrombus formation and inducing the disaggregation of thrombi already formed. The complexes can be formulated into pharmaceutical compositions in conventional manner.
机译:前列环素和前列环素衍生物与环糊精形成包合物。可以通过使环糊精的水溶液与前列环素或其衍生物接触,优选在有机溶剂溶液中,来制备复合物。与未络合的化合物相比,包合物具有更高的稳定性,尤其是在水溶液中,并且在抑制血栓形成和诱导已经形成的血栓分解方面非常有效。可以按照常规方式将复合物配制成药物组合物。

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