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THIADIAZINE, OXADIAZINE AND TRIAZINE DERIVATIVES WHICH POSSESS CARDIOTONIC AND/OR ANTIHYPERTENSIVE ACTIVITY

机译:噻嗪嗪,乙二嗪和三嗪衍生物具有无心律和/或抗高血压活性

摘要

Heterocyclic compounds of the formula: IMAGE wherein either X is -CR1R2- and Y is -O-, -S- or-NHR3-, wherein R1, R2 and R3, which may be the same or different, each is hydrogen or alkyl of up to 4 carbon atoms; or X is -O-, -S- or -NH- and Y is -CR1R2- wherein R1 and R2 have the meanings stated above; wherein R4 and R5, which may be the same or different, each is hydrogen (but provided that R4 and R5 are not both hydrogen), or each is a group defined in claim 1 which is readily convertible into a carboxy group; processes for their manufacture; and pharmaceutical compositions containing them. The compounds possess cardiotonic and/or antihypertensive activity.
机译:下式的杂环化合物:其中X是-CR 1 R 2-且Y是-O-,-S-或-NHR 3-,其中R 1,R 2和R 3可以相同或不同,各自为氢或最多4个碳原子的烷基; X为-O-,-S-或-NH-,且Y为-CR1R2-,其中R1和R2具有上述含义;或其中R 4和R 5可以相同或不同,各自为氢(但前提是R 4和R 5均不为氢),或各自为易于转化为羧基的权利要求1所定义的基团;生产过程;以及含有它们的药物组合物。该化合物具有强心和/或抗高血压活性。

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