TRICYCLIC ANTIDEPRESSANT DRUG IMMUNOGENS,ANTIBODIES PREPARED THEREFROM,LABELED CONJUGATES AND RELATED DERIVATIVES AND THE USE OF SUCH ANTIBODIES AND LABELED CONJUGATES IN IMMUNOASSAYS FOR DETERMINING SUCH DRUGS

摘要

Tricyclic antidepressant drug (e.g., imipramine, desipramine, amitriptyline, or nortriptyline) immunogens, antibodies prepared therefrom, labeled conjugates, synthetic intermediates, and the use of such antibodies and labeled conjugates in immunoassays for determining such drug. The immunogens comprise the drug coupled at its 2'-position to an immunogenic carrier material. Similarly, the labeled conjugates and synthetic intermediates are 2'-derivatives of the drug or a precursor thereof. The antibodies and labeled reagents are particularly useful in certain homogeneous nonradioisotopic immunoassays for measuring tricyclic antidepressant drugs in biological fluids such as serum.