METHOD AND ROUTE(S) OF ADMINISTRATION FOR THE PREPARATION AND/OR PREPARATION OF A PHARMACEUTICAL SUBSTANCE APPROVED WITH A 4-OMEGA (CUMARINE-7-YLOXY) ALKYL PIPERAZINE MEDICINAL PRODUCT AND ROUTE(S) OF ADMINISTRATION FOR THERAPEUTICAL USE

摘要

1335946 Coumarin-7-yloxyalkyl-piperazine derivatives BOEHRINGER MANNHEIM GmbH 11 May 1972 [14 May 1971] 22070/72 Heading C2C Novel compounds of the Formula (I) wherein R 1 is a hydrogen atom or a C 1-5 alkyl radical, R 2 is a C 1-5 alkyl radical, R 3 is an unsubstituted or substituted phenyl or benzyl radical, the substituents, when present, being halogen atoms or C 1-5 alkyl or C 1-5 alkoxy radicals, and n is 1, 2 or 3; and the pharmacologically compatible salts thereof, may be obtained by (a) condensing a compound of the Formula (II) in which X is a halogen atom, with a 7-hydroxy- 3 - R 1 - 4 - R 2 - substituted - coumarin, (b) condensation of a compound of the Formula (IV) with an R 3 -substituted-piperazine, (c) condensation of a compound of Formula (I), in which R 3 is H, with a compound of the formula X.R 3 , in which R 3 is an unsubstituted or substituted benzyl radical; or (d) condensation of a compound of the Formula (VII) with an amine of formula H 2 N-R 3 , and thereafter, if desired, converting the products into their physiologically compatible salts. Pharmaceutical compositions having antiinflammatory and anti-allergic action comprise at least one compound of the Formula (I) in admixture with a solid or liquid pharmaceutical diluent or carrier, for example in the form of tablets or dragees or suspended or dissolved in water or an oil.