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adenosinici derivatives for anti-inflammatory and analgesic activity, and therapeutic compositions which contain them as active principle
adenosinici derivatives for anti-inflammatory and analgesic activity, and therapeutic compositions which contain them as active principle
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机译:具有抗炎和镇痛作用的腺苷衍生物以及以它们为有效成分的治疗组合物
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摘要
A therapeutic composition of antiinflammatory, analgesic and antipyretic activity comprises as its active principle, at least one component of the general formula: IMAGE in which R is a linear or branched alkyl radical containing 1-18 C atoms or a phenylalkylene in which the alkylene chain contains 1-6 C atoms; R1 is H, an aliphatic acyl radical containing 1-6 C atoms or an aromatic acyl radical; R2 is H, an aliphatic acyl radical containing 1-6 C atoms, or an aromatic acyl radical, or the radicals R2 together form an isopropylidene chain; and N is 0 or 1, or an acid additive salt of a compound of formula (I) in which R' is hydrogen. Various methods of preparing compounds of formula (I) are disclosed including a method of preparing 5'-deoxy-5'-methylthiodenosine by hydrolysing a concentrated aqueous solution of S-adenosyl-methionine by heating under reflux, neutralising the reaction mixture and cooling it to separate the 5'-deoxy-5'-methylthioadenosine formed.
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机译:抗炎,止痛和解热活性的治疗组合物包括至少一种通式的成分:[IMAGE],其中R是含有1-18个碳原子的直链或支链烷基或苯基亚烷基,其中亚烷基链含有1-6个碳原子; R1为H,含有1-6个碳原子的脂族酰基或芳族酰基; R 2为H,含有1-6个碳原子的脂族酰基或芳族酰基,或基团R 2一起形成异亚丙基链; N为0或1,或R′为氢的式(I)化合物的酸加成盐。公开了各种制备式(I)化合物的方法,包括通过在回流下加热水解S-腺苷甲硫氨酸的浓水溶液,中和反应混合物并将其冷却来制备5'-脱氧-5'-甲基硫代腺苷的方法。分离形成的5'-脱氧-5'-甲基硫代腺苷。
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