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VACCINE FOR PREVENTION OF GASTROENTERIC DISEASE:NON-PATHOGENIC STRAIN GENETICALLY ENGINEERED TO COMPRISE GENES FOR ADHESIN AND/OR TOXOIDS
VACCINE FOR PREVENTION OF GASTROENTERIC DISEASE:NON-PATHOGENIC STRAIN GENETICALLY ENGINEERED TO COMPRISE GENES FOR ADHESIN AND/OR TOXOIDS
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机译:预防胃肠道疾病的疫苗:遗传工程改造的非致病性菌株,包含adhesesin和/或毒素的基因
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摘要
A vaccine is described for prevention of gastroenteric disease caused in a mammalian species by a pathogenic microorganism and which avoids, in its manufacture, the use of pathogens (which must be attenuated or killed) and the attendant risks, costs and complexity. The present vaccine comprises a nonpathogenic microorganism strain containing stable replicative plasmids, each having one or more genes non-indigenous to the plasmid. The non-indigenous genes are either genes for an adhesin necessay for adherence of the pathogenic microorganism in the mammalian species or are genes for toxoids of toxins causative of the disease. Both types of genes may also be included in the same plasmid. The invention includes the method of manufacture of such vaccines and their use in stimulating the production of antibodies.
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