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PROCESS FOR THE PREPARATION OF APOVINCAMINATES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
PROCESS FOR THE PREPARATION OF APOVINCAMINATES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
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机译:制备芹菜素和含有它们的药物组合物的方法
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摘要
A process is disclosed for the preparation of racemic cis or trans apovincaminic acid esters of the formula (I) IMAGE (I) and the corresponding optically active derivatives of the formulae (Ia) IMAGE (Ia) and/or (Ib) IMAGE (Ib) and/or (Ic) IMAGE (Ic) and/or (Id) IMAGE (Id) wherein R1 and R2 are identical or different alkyl groups having 1 to 6 carbon atoms. Apovincaminic acid alkyl esters are well-known vasodilating compounds.
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