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process for the production of new 1.4 and 3.6 - dianhydro - 2.5 - 2.5 - diazido didesoxy - hexit derivatives
process for the production of new 1.4 and 3.6 - dianhydro - 2.5 - 2.5 - diazido didesoxy - hexit derivatives
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机译:的生产新的1.4和3.6-二氢-2.5-2.5-二叠氮双脱氧己酮衍生物的方法。
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摘要
The invention relates to new stereoisomeric 1,4;3,6-dianhydro-2,5-diazido-2,5-dideoxy-hexitols of the Formula I. These compounds can be prepared by (a) reacting a hexitol derivative of the general Formula II /wherein R is a mesyl or tosyl group/ in an aqueous or anhydrous organic solvent with an alkali metal azide or ammonium azide; or (b) mesylating or tosylating a compound of the Formula III and treating the mixed ester of the general Formula IV thus obtained /wherein R is as stated above/ with a base; or (c) subjecting a compound of the Formula III to debenzoylation and subsequently to partial esterification and treating the compound of the general Formula V thus obtained /wherein R is as stated above/ with a base. The new compounds of the Formula I possess valuable hypnotic properties and can be used in therapy. FORMULAE IMAGE [I] IMAGE [II] IMAGE IMAGE IMAGE
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