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A procedure of preparation of New Derivatives of the diclorados Pregnane Series - methyl - 16 -
A procedure of preparation of New Derivatives of the diclorados Pregnane Series - methyl - 16 -
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机译:Dilorados Pregnane系列新衍生物-甲基-16-的制备方法
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摘要
Preparation method of New Derivatives of the series 16-bab-metil-pergnano.co diclorados nsiste in preparing products of formula (i) in which R represents a radical trimetilsililfenilo, ciclododeciloxi, diciclopentilmetoxi or ciclohexilmetoxi.9bab is reacted, 11 - Dichloro - 16 - Bab - methyl - 21 - ipregna Hydrox - 1.4 - dien - 3,20 Dione - a product of formula (ii), in which Hal is a Halogen Atom and R have the meaning indicated above, and obtains the expected product. Hal is preferably a Chlorine Atom or Bromine and the Reaction is carried out in presence of a base such as Pyridine or collidine Agent.Have pharmacological Application especially as anti-inflammatory.
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