SHORT TOTAL SYNTHESIS OF DIHYDROTHEBAINONE, DIHYDROCODEINONE AND NORDIHYDROCODEINONE

摘要

ABSTRACT OF THE DISCLOSUREA method of producing morphinan compounds whichincorporates double advantages over the prior art, suchas the utilization of .beta.,.gamma.-unsaturated ketones in placeof the .alpha.,.beta.-unsaturated ketones previously used. Additionally,in the step where .beta.,.gamma.-unsaturated bromoketones proceedto 1-bromo-N-formylnordihydrothebainone (morphinan) thereare utilized super acids, such as trifluoromethane sul-fonic, trifluoroethane sulfonic and mixtures thereof, andalso antimony pentafluoride and mixtures of hydrogenfluoride and antimony pentafluoride. Super acids work,whereas the prior art shows that cyclization in the pres-ence of acids, even strong acids, such as sulfuric, phos-phoric, do not work.