2-AMINO-3- HYDROXY PHENYL METHYL PHENYL ACETIC ACIDS, SALTS, ESTERS AND AMIDES.

摘要

2-Amino-3-[hydroxy(phenyl)- methyl]phenylacetic acids, metal salts and hydrates thereof, esters and amides having the formula: IMAGE are disclosed wherein R1 represents a hydrogen atom or a loweralkyl group; R2 represents an -OH, -OM, -O-loweralkyl or -NR3R4 group; R3 and R4 represents a hydrogen atom or a loweralkyl, cycloalkyl or phenyl group, or a phenyl group substituted by one or more loweralkyl, loweralkoxy, or trifluoromethyl groups or halogen atoms an R3 and R4 taken together with the adjacent nitrogen may form a heterocyclic residue; M represents a pharmaceutically acceptable cation or fraction thereof when the cation is multivalent; Am represents a primary amino or dimethylamino group; X represents a hydrogen or a halogen atom or a loweralkyl or trifluoromethyl group, Y represents a hydrogen or halogen atom or a lower alkyl, loweralkoxy, trifluoromethyl or methylthio group; and n is 1 to 3 inclusive and when n is greater than one, Y may be the same or different and hydrates of all such compounds. The compounds have anti- inflammatory, anti-pyretic, analgesic and blood-platelet-aggregation- inhibiting activities.