Peptide, a process for producing the heptacosapeptide and the use of the heptacosapeptide for producing secretin

摘要

A heptacosapeptide is disclosed having the following structural formula:;Boc-His(Boc)-Ser(Bu^t)-Asp(OBu^t)-Gly-Thr(Bu^t)-Phe-Thr(Bu^t)-Ser(Bu^t)-Glu(OBu^t)-Leu-Ser(Bu^t)-Arg(X)-Leu-Arg(X)-AsplOBu^t)-Ser(Bu²1-Ala-Arg(X)-Leu-Gln-Arg(X)-Leu-Leu-Gln-Gly-Leu-Val-NH2, in which X is a group having the formula:where R is an alkyl or alkoxy and m is an integer of 1 to 3, provided that R's may be the same or different in case m is 2 or 3. Said heptacosapeptide can be produced by condensation of a novel decapeptide with a heptapeptide which are also disclosed. The heptacosapeptide can be used for production of a secretin.