PROCESS FOR PREPARING 6- -SUBSTITUTED PENICILLANIC ACIDS

摘要

The title compds. (I; R15=F, Cl, Br, iodo, C1-4 alkoxy, C1-4 alkylthio; R13=H, ester; n=o 1, 2) were prepd. as -lactamase inhibitors for -lactam antibiotic formulations. Thus, 2.95g Na 6-chloro-6-iodopenicillanic acid was dissolved in 125mL benzene and treated with 1.08mL Et3N. This mixt. was reacted with 0.977mL trimethylcillyl chloride and refluxed with 15mg azobisisobutyronitrile and 2.02mL tri-n-butylene-HCl to give Na 6--chloropenicillanic acid.