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PROCESS FOR PREPARING NOBEL CEPHEM COMPOUND
PROCESS FOR PREPARING NOBEL CEPHEM COMPOUND
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机译:诺贝尔头孢烯化合物的制备过程
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摘要
Cephalo I [R1=(shielded) amino; R2=alkyl, (protection) aminoalky1, hydroxyalkyl, alkythioakyl, carboxyalkyl, alkenyl, alkynyl, naphthenic base, as ETX. ; R3=(protection) aminoalkyl, hydroxyalkyl, etc.; R4=(protection) carboxyl; It is to be ready to as R3=hydrocyalkyl, ETX when R2=lower alkyl. Therefore syn-7- [2- (2-formamidothiazole-4-yl) -2-methoxyiminoacetamido -3- [1- (2-hydroxythyl-lh-tetrazol-5-yl sulfidomethyl -3-cephem-4-carboxylic acid and 0.73g concentration. HCl and 14.The methanol of 0g 32 hours. In room temperature. To provide 7- [2-aminothiazole-4-yl -2-methoxyiminoacetamido -3- [1- (2-hydroxyethyl-l-tetrazole-5yl sulfidomethyls -3-cephem-4-carboxylic acid.
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