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NON IONIC 5-C-SUBSTITUTED 2,4,6-TRIIODO-ISOPHTHALIC ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION AND X-RAY CONTRAST AGENTS CONTAINING THEM
NON IONIC 5-C-SUBSTITUTED 2,4,6-TRIIODO-ISOPHTHALIC ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION AND X-RAY CONTRAST AGENTS CONTAINING THEM
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机译:非离子5 C取代的2,4,6-三碘-异邻苯二甲酸衍生物,其制备方法和含有它们的X射线对比剂
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1. Compounds of the general formula I see diagramm : EP0032387,P17,F5 in which X represents the radical -CO.N.R1 R2 , -CCOR3 , -CH2 .NH.R7 or -CH2 OH, Y represents the radical -N.R1 R2 or -OR3 , Z represents the radical -N.R1 R2 , -NH.R7 , -NH.(sugar radical) or -OR3 , -N.R1 R2 in X, Y and Z being the same or different, R1 and R2 are the same or different and represent a hydrogen atom or a straight-chain or branched-chain alkyl radical having from 1 to 6 carbon atoms or a mono- or polyhydroxylated straight-chain or branched-chain alkyl radical having from 2 to 8 carbon atoms and from 1 to 5 hydroxy groups, R3 represents an alkyl radical having from 1 to 4 carbon atoms or a hydroxylated alkyl radical having from 2 to 4 carbon atoms and from 1 to 3 hydroxy groups, and R7 represents the acyl radical of an aliphatic carboxylic acid having from 2 to 5 carbon atoms which may optionally be substituted by from 1 to 5 hydroxy groups, it being possible for the hydroxy groups also to be functionally modified.
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