首页>
外国专利>
PROCESS FOR THE DEGRADATION OF THE C20-CARBOXYLIC GROUP OF DELTA-4-BNC COMPOUNDS OPTIONALLY CONTAINING OTHER DOUBLE BONDS, AS WELL AS C-21 STEROIDS
PROCESS FOR THE DEGRADATION OF THE C20-CARBOXYLIC GROUP OF DELTA-4-BNC COMPOUNDS OPTIONALLY CONTAINING OTHER DOUBLE BONDS, AS WELL AS C-21 STEROIDS
展开▼
机译:可选地包含其他双键以及C-21甾体的DELTA-4-BNC化合物的C20-羧基基团的降解过程
展开▼
页面导航
摘要
著录项
相似文献
摘要
DELTA 4-Steroid-20-carboxylic acids (BNC compounds) which may optionally contain at least one other double bond in the 1(2)- and/or 9(11)-position and which may also contain an oxygen function, particularly a hydroxyl group or a keto group, in the 11-position, are degraded in the 20-carboxyl group by carboxy inversion degradation. To achieve this, the BNC-carboxylic acids are first transformed into their acid halides which are reacted with peracids to form mixed acid anhydrides, followed by hydrolysis. The reaction product obtained is a mixture of 20-hydroxy- and 20(21)-ene-steroid compounds which contain one carbon atom less than the starting material used. New and known C21-steroid compounds can be produced by the process. The C21-steroid compounds having an oxygenated function in the 11-position may be processed to prednisolone and prednisone by known procedures.
展开▼