Polymer latex for biological application - comprises spherical core particles of acrylic! ester polymer surrounded by vinyl! aromatic polymer particles

摘要

Latex comprises an aq. dispersion of particles comprising an acrylic ester polymer core surrounded by a vinyl aromatic polymer. The particles are at a concn. less than 60 wt.%, have a density of 1.07-1.2, a homogeneous dia. of 0.1-2 microns, have irregular profiles and comprise 50-95 wt.% of a spherical core of (1-4C)alkyl (meth)acrylate homo- or co-polymer and 5-50% of peripheral particles of the vinyl aromatic polymer bonded to the core. Pref. the core has a density of 1.1-1.2. The latex is claimed for the fixation of proteins and the prepn. of diagnostic reactants (I), e.g. the latter are prepd. by fixation, on the latex polymer, of antigenes or antibodies which can react specifically with an antagonistic antigen or antibody. The relatively low density of the latex particles facilitates decantation during prepn. of the reactants (I) without the need of having a high particle dia..