TRITIUM-LABELLED RADIOACTIVE ESTRADIENE DERIVATIVES, MANUFACTURE, INTERMEDIATES, EXAMINATION OF STEROID IN VIVO STREAM AND USE FOR RADIOIMMUNODETERMINATION

摘要

Novel radioactive estradienes labelled with tritium of the formula IMAGE I wherein 3H is tritium and R is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms and acyl of an organic carboxylic acid of 1 to 10 carbon atoms and the study and radioimmunological determination of non-radioactive 11 beta -(4-dimethylaminophenyl)-17 alpha -(prop-1-ynyl)- DELTA 4,9-estradiene-17 beta -ol-3-one and its metabolites in biological fluids and novel intermediates.