首页>
外国专利>
MODIFIED ANTIGEN, ITS PREPARATION AND PREVENTIVE AND REMEDY FOR ALLERGIC DISEASE CONTAINING THE SAME
MODIFIED ANTIGEN, ITS PREPARATION AND PREVENTIVE AND REMEDY FOR ALLERGIC DISEASE CONTAINING THE SAME
展开▼
机译:修饰的抗原,包含该抗原的过敏性疾病的制备,预防和治疗
展开▼
页面导航
摘要
著录项
相似文献
摘要
PURPOSE:To provide a modified antigen composed of a polymer of an aspartic acid derivative bonded chemically to an antigen causing allergic diseases, and useful as a preventive and remedy for allergic diseases. CONSTITUTION:The compound of formula I (R1 is hydroxyalkyl; R2 is aminoalkyl; R is R1 or R2; n and n' are number of residues bonded to beta-position; m and m' are number of residues bonded to alpha-position; n+n'+m+m' is 6-3,000; n'+m' is 0-1,500) is bonded to an antigen by covalent bond directly or indirectly with 2,4,6-trichloro-S-triazine, 2,4-dichloro-6-methoxy-S-triazine, etc. The compound of formula I can be prepared by reacting the anhydropolyaspartic acid of formula II with the compound of formula NH2-R1 and NH2-R2. The antigen is e.g. hapten, respiratory antigen, alimentary antigen, enzymatic preparation, biological preparation, product from genetic operation, etc.
展开▼
机译:目的:提供一种修饰的抗原,该抗原由天冬氨酸衍生物的聚合物化学结合而成,该抗原与引起过敏性疾病的抗原结合,并可用作预防和治疗过敏性疾病的方法。组成:式I化合物(R1为羟烷基; R2为氨基烷基; R为R1或R2; n和n'为键合至β位的残基数; m和m'为键合至α位的残基数; n + n'+ m + m'为6-3,000; n'+ m'为0-1,500)直接或间接与2,4,6-三氯-S-三嗪2,可以通过使式II的脱水聚天冬氨酸与式NH 2 -R 1和NH 2 -R 2的化合物反应来制备式I的化合物。抗原是例如半抗原,呼吸道抗原,消化道抗原,酶制剂,生物制剂,遗传操作产物等。
展开▼