This invention encompasses novel 5-¢1,1-diphenyl-3-(5-or 6-hydroxy-2-azabicyclo¢2.2.2!oct-2-yl)-propyl!-2-alkyl-1,3,4-oxadiazoles and their lower Oalkanoyl derivatives. These compounds are useful antidiarrheal agents and also possess little or no analgesic activity. These compounds are prepared by reacting the appropriate tetrazoles in the presence of a solvent such as pyridine with a suitable anhydride or acid chloride to give the oxadiazoles, optionally followed by alkaline hydrolysis to yield the 5-or 6-hydroxy compounds.
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