4 - ((E) -2- (4,4-dimethyl-6-chromanyl, -thiochromanyl or 1,2,3,4-tetrahydroquinolinyl) -2-vinyl) benzoic acid or phenylacetic acid compounds, processes for preparing thereof, and pharmaceutical composition containing these compounds

摘要

Certain carboxylic acids of the formula CHEM and the pharmaceutically-acceptable salts thereof, and certain esters and amides thereof, are useful for inhibiting the degradation of articular cartilage when administered to a mammalian subject afflicted with an arthritic disease. X is O, S, SO, SO2, NH, NCH3 or NCOCH3; R1 is H or CH3; and n is zero or one.