pyridinderivater, procedure for their preparation and pharmaceutical compositions containing the relations

摘要

There are described compounds of formula I, CHEM in which R2 and R3, which may be the same or different, each represent alkyl C1 to 6 or cycloalkyl C3 to 8, R7 and R8, which may be the same or different, each represent alkyl C1 to 6 optionally substituted by halogen, and X, Y and Z, which may be the same or different, are each hydrogen, halogen, nitro or alkyl C1 to 6 optionally substituted by halogen, or Z is as defined above and X and Y, together with the carbon atoms to which they are attached, form a C5 to 8 carbocyclic ring, other than a benzene ring, provided that when R2, R3, R7 and R8 are all methyl and X and Z are hydrogen; or when R2 and R3 are both ethyl, R7 and R8 are both ethyl and X and Z are hydrogen; then Y is other than methyl. There are also described methods for making the compounds and their formulation and use as pharmaceuticals, e.g. for the treatment of cardiovascular conditions.