chemical compounds with beta blocker activity, method for their manufacture, compositions containing the relations and the application in the medicine

摘要

The invention relates to compounds of formula (I), physiologically acceptable salts thereof, formulations containing them, their preparation and their use in medicine. In formula (I) CHEM Q and Q1-Q8 are independently selected hydrogen and C1-4 alkyl; A is a group of formula -(CO)k-(NQ9)m-(CH2)n- where k and m are either both 0 or both 1, n is from 1 to 6, Q9 is selected from hydrogen and C1-4 alkyl and any of the -(CH2)n- groups independently are optionally substituted by one or two C1-4 alkyl groups; B is a C1-6 alkyl group; E and Z are independently selected from carboxy derivatives thereof; D is hydrogen or a C1-6 alkyl group which is optionally substituted by an amino group; (X) is a benzene ring or a naphthyl or indolyl ring system any of which is optionally substituted in any position by one or more substituents independently selected from C1-4 (itself optionally substituted by one or more halogen atoms (C1-4 alkoxy, halo, nitro, amino, carboxy, C1-4 alkoxycarbonyl and hydroxy; and -N Y is a pyrrolidinyl, oxazolidinyl or thiazolidinyl ring, or a ring system selected from indolinyl, quinolinyl and tetrahydroquinolinyl.