首页>
外国专利>
PROCESS FOR PRODUCING RIPE,INSULINE-LIKE GROWING FACTORS WITH HIBRIDE DNA SYNTHESIS
PROCESS FOR PRODUCING RIPE,INSULINE-LIKE GROWING FACTORS WITH HIBRIDE DNA SYNTHESIS
展开▼
机译:杂交DNA合成生产梨状,胰岛素样生长因子的方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
Prodn. of human insulin-like growth factor (IGF) comprises growing host cells contg. a structural gene which comprises a functional DNA construct of the gene encoding IGF joined in proper reading frame with secretory leader and processing signal sequences recognised by the host, and isolating secreted human IGF. The structural gene is downstream from and under transcriptional regulatory control of a transcriptional initiation region in a vector compatible with the host. The host is pref. a yeast. A DNA construct comprising a coding sequence for human IGF under transcriptional regulation of regulatory signals utilised by yeast is new. Also claimed is a construct contg. the IGF gene for expression in a cultured cellular host. Nucleotide sequences are defined with corresp. aminoacid sequence.
展开▼