首页> 外国专利> method for preparation of medicines with anti tumour activity on the basis of anthracycline glycosides and method for preparation of this relevant anthracycline glycosides.

method for preparation of medicines with anti tumour activity on the basis of anthracycline glycosides and method for preparation of this relevant anthracycline glycosides.

机译:蒽环糖苷为基础的具有抗肿瘤活性的药物的制备方法和相关蒽环苷的制备方法。

摘要

New anthracycline glycosides designated MA 144-G1, -G2, -L, -S1, -N1, -U1 and -Y which inhibit the growth of gram-positive bacteria and mammalian tumors are produced by fermentation of certain species of Streptomyces and by the chemical or enzymatic conversion of certain anthracycline glycosides. New microbiological and chemical processes are also provided for preparation of the anthracycline glycosides MA 144-S2 and -U2 which have been found to be identical with the previously reported anthracyclines, marcellomycin and musettamycin.
机译:通过某些链霉菌的发酵以及通过链霉菌的发酵产生新的蒽环类糖苷,它们被命名为MA 144-G1,-G2,-L,-S1,-N1,-U1和-Y,它们抑制革兰氏阳性细菌和哺乳动物肿瘤的生长。某些蒽环类苷的化学或酶转化。还提供了新的微生物学和化学方法来制备蒽环类苷MA 144-S2和-U2,它们已被发现与先前报道的蒽环类,马赛霉素和Musettamycin相同。

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