6-Phenyl thio- and 6-cyclohexyl thio-2,3,4,5-tetrahydro-1H-3- benzazepines

摘要

2,3,4,5-Tetrahydro-1H-3-benzazepines represented by the formula: CHEM wherein: R is methyl, allyl, dimethylallyl, phenethyl, cyclopropylmethyl or beta -hydroxyethyl; R1 is phenyl, m- or p-substituted phenyl with the substituent being trifluoromethyl, chloro, methoxy, methyl, fluoro, nitro or hydroxy, cyclohexyl, thienyl, thienylmethyl, fury or furylmethyl; R2 is hydrogen, methoxy, alkanoyloxy with the alkanoyl moiety having from 2 to 6 carbon atoms, or hydroxy, each R2 being the same or different except that when one of R2 is alkanoyloxy the other is hydrogen, methoxy or alkanoyloxy; and R3 is hydrogen, chloro, bromo, trifluoromethyl, fluoro or methyl, or a nontoxic pharmaceutically acceptable acid addition salt thereof, process for their production and pharmaceutical compositions having dopamine receptor blocking activity.