PROCESS FOR THE PREPARATION OF ANALGESIC COMPOSITIONS CONTAINING 17-(CYCLOPROPYLMETHYL)-X-(1,1-DIMETHYETHYL)-4,5-EPOXY-18,19-DIHYDRO-3-HYDROXY-6-METHOXY-ALPHA-METHYL-6,14-ETHENOMORPHINANE-7-METHANOL AND 1-N-ALYL-14-HYDROXYNORDIHYDROMORPHINONE

摘要

A method of treating pain which comprises the administration to a patient of a parenterally or sublingually effective dose of buprenorphine together with an amount of naloxone sufficient to prevent substitution in an opiate dependent subject. Preferably when the administration is parenteral the weights of naloxone and buprenorphine are within the ratio of 1:3 to 1:1 and when administered sublingually the weights are within the ratio of 1:2 to 2:1.