A process for the preparation of Acid 6, 6 - methoxy -, B - (2 - (metilfenoxicarbonil) - 2 - (3 - il - penicillanic) acetamido)

摘要

Method for preparing ACID 6, Bab 6 - methoxy -, BBB - 2 - (metilfenoxicarbonil) - 2 - (Tien - 3 - il) acetamidopenicilanico.consiste in reacting a compound of formula (ii) with Methanol in the presence of a Metal Ion, such as a Salt of Tellurium, Lead, Silver, Copper, Bismuth, Mercury, Lead, CA Dmio or Thallium, to obtain compounds of formula (i).Then carrying out: Remove any Substituent of the amido Group; separate the blocker RX carboxy Group; and converting the product into a Salt or an ester Hydrolyze in vivo. RX is a blocker of carboxy Group and R4 is c 1-6 alkyl, Benzyl, or an aryl Group. The reaction is carried out between c50jc b25jc and temperature.Have Pharmaceutical Application for its activity against Gram negative bacteria.