Procedure for the production of N - Acyl - polypeptides (such as Breakdown and priority of the Spanish Patent 510.167 n, submitted on 5 March 1982).

摘要

Procedure for the production of n-acilo-polipeptidos.consiste: (a) to oxidize a n - Acyl - polypeptide of formula (i) where Y1 and Y2 are h, solvent, in the presence of Atmospheric oxygen and temperature between c10jc and 70jc to obtain (i), where Y1 and Y2 are a direct link; and B Recover) (i) was to stage a) in free form, of a compound or Salt.Acyl acyl: rest, being an organic or inorganic acid; c, H or alkyl of 1 to 3 CH; n - (Z) - CO - (L) - A REST, or (d) - eventually substituted phenylamine in the Ring by NH2, NO2, Z, the rest remaining N - ch - (Z) - CO; b, PHE eventually substituted in the Ring by NH2 or NO2, C, or D - TRP TRP EV Entualmente Bab - N - methylated Lys eventually Bab; D - N - methylated; and,A Rest Bab - amino acid of a d-amino acid; f or a Group - coor - ch2or2; and R1 and R2 are H.