N-substd.-flavone-8-carboxamide derivs. - useful for treating dysuria by removing hindrances to micturition

摘要

Cpds. of formula (I) and their acid-addn. salts are new. (R1 is H, Me or Et R2 is H, lower alkyl, lower alkoxy, halogen or NO2 R3 is H or lower alkyl k is 0-3 m is 0 or 1 X and Y are H or Me A is NR4R5, N-R6-pyrrolidinyl or N-6-piperidinyl R4 and R5 are lower alkyl or NR4R5 is cyclic amino opt. contg. an O atom R6 is lower alkyl and n is 2 or 3). Cpds. (I) remove hindrances to micturition e.g. in cystitis or prostatitis and so are useful for treating dysuria they have sufficient stability against acids and non-specific esterases for oral admin. Dose is 100-200 mg 3 times daily orally.