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New 1-phenyl-2-amino-1-propanol derivs. - useful as cardioactive agents with positive inotropic activity
New 1-phenyl-2-amino-1-propanol derivs. - useful as cardioactive agents with positive inotropic activity
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机译:新的1-苯基-2-氨基-1-丙醇衍生物。 -可用作具有正性肌力活动的心脏活性剂
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摘要
1-(Alkyl-hydroxy-phenyl)-2 -alkylamino-1-propanols of formula (I) and their acid-addn. salts are new. In (I), R1 = 1-4C alkyl; R2 = (a) phenyl opt. substd. by halogen, OH, 1-6C alkyl or 1-6C alkoxy, or (b) 5-6C cycloalkyl opt. substd. by 1-6C alkyl or alkoxy; A = 3-4C alkylene. Pref. R1 = Me in the 3- or 4-posn. (the OH gp. being in the 4 or 3 posn.); R2 = phenyl, 4-chlorophenyl or 4-fluorophenyl; A = (CH2)3.
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机译:式(I)的1-(烷基-羟基-苯基)-2-烷基氨基-1-丙醇及其酸加成基。盐是新的。在(I)中,R 1 = 1-4C烷基; R 2 =(a)苯基。取代选用卤素,OH,1-6C烷基或1-6C烷氧基,或(b)5-6C环烷基。取代1-6C烷基或烷氧基; A = 3-4C亚烷基。首选R1 = 3点或4点的Me。 (OH gp。在4或3位置。); R2 =苯基,4-氯苯基或4-氟苯基; A =(CH2)3。
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