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MANUFACTURE OF COLLAGEN TUBES AND THEIR APPLICATION TO VASCULAR PROSTHESES AND NERVE SUTURES
MANUFACTURE OF COLLAGEN TUBES AND THEIR APPLICATION TO VASCULAR PROSTHESES AND NERVE SUTURES
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机译:胶原管的制造及其在血管修复和神经缝合中的应用
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摘要
A process for preparing collagen tubes includes extruding an aqueous gel containing about 1.5% native collagen through a cylindrical spinneret equipped with a central concentric tube designed to receive a part of a coagulation bath, followed by coagulation of the internal and external walls of the tube, leaving the spinneret in a coagulation bath constituted by about 70% acetone and 30% ammonia, followed by drying. Following drying, the collagen tube may be subjected to reticulation by dehydration carried out at about 80 DEG C. under a pressure of about 0.1 mm of Hg (vacuum) for about 24 hours. The reticulated collagen tube may eventually be subjected to a treatment which permits the introduction of azide groups onto the molecule without requiring that the collagen be coupled to any external molecule.
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