Method of manufacturing tubes from collagen, and its use in the field of vascular prostheses and nervous systems

摘要

This manufacturing method comprises the following stages: extrusion into a cylindrical die (2) equipped with a concentric central pipe (3) for receiving a portion of the coagulating bath (5), an aqueous acid gel (4) containing 1.5% of native collagen, followed by coagulation of the internal and external walls of the tube emerging from the die into a coagulating bath (5) consisting of about 70% acetone to 30% of ammonia, and drying.; Once dried, the collagen tube (8) is subjected to crosslinking in an oven thrust dehydration at about 80 ° C under a vacuum of about 0.1 mm of mercury for about 24 hours.; Collagen tube (8) is cross-linked optionally subjected to a treatment for introducing azide groups in the molecule without however causing the collagen coupling with any molecule whatsoever.