An intrauterine device for the type having an external surface contacting the walls of the uterus after insertion therein, and said device having first walls defining a fluid receiving cavity in at least a portion thereof. A concentrated fluid solution of a drug is present in the cavity and the drug is of the type providing an antifertility and antiproteolytic effect and is selected from the group consisting of amidines, such as aromatic monoamidines, aromatic diamidines and non-aromatic diamidines, guanidines, such as aromatic mon0guanidines, aromatic diguanidines, non-aromatic monoguanidines and non-aromatic diguanidines, and mixtures thereof.
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