3-AMINO-5-SUBSTITUTED-6-HALO-N-(3,4-DIHYDRO- OR 4,4-DISUBSTITUTED-6-SUBSTITUTED-1,3,5-TRIAZIN-2-YL)-2-PYRAZINECARBOXAMIDES, PROCESS FOR PREPARING AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

摘要

This invention relates to 3-amino-5-substituted-6- halo-N-(3,4-dihydro- or 4,4-disubstituted-6-substituted- 1,3,5-triazin-2-yl)-2-pyrazinecarboxamides. The invention also relates to processes for preparing those compounds of the formula of the tautomeric form thereof CHEM wherein R is hydrogen,, C1-5 alkyl, C2-5 alkenyl or C3-6 cycloalkyl; R1 is hydrogen, C1-5 alkyl, C2-5 alkenyl or C3-6 cycloalkyl; R2 is hydrogen, or C1-5 alkyl; R3 is hydrogen, or C1-5 alkyl; R2 and R3 can be joined with the carbon atom to which they are attached to form a 3-7 membered carbon ring; X is halo Y is OH, SH, C1-5 alkoxy, C1-5 alkylthio and NR4R5 wherein R4 is hydrogen or C1-5 alkyl and R5 is hydrogen, C1-5 alkyl, CN, CONH2, CNH2, NO2 or NH2 NH and the pharmaceutical acid addition salts thereof. The compounds are eukalemic/saluretic agents useful in the treatment of edema and hypertension.