Compounds and compositions, cytostatics and analgesics high and preparation.

摘要

Compounds having cytostatic, hypotensive and analgesic activity of the formula IMAGE in which: R1 represents IMAGE in which X represents a hydrogen atom or an alkyl, cycloalkyl, aryl, hydroxyaryl or arylalkyl group, R2 represents a hydrogen atom, an alkyl or aryl group or R1, R3 and R4 independently represent a hydrogen atom or an alkyl or aryl group or R3 and R4 together represent IMAGE in which R5, R6, R7 and R8 independently represent a hydrogen atom or an alkyl or aryl group, or R5 and R6 together may form =O in which case R8 may represent IMAGE in which R9 and R10 independently represent a hydrogen atom or an alkyl or aryl group maybe prepared by reaction in aqueous media of: (a) an aldehyde or ketone of the formula: IMAGE and (b) an enediol of the formula: IMAGE