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Complex platinum - diamine, a method of production, the application of such a complex for obtaining a medicinal product for the treatment of cancer and medicinal product thus obtained.
Complex platinum - diamine, a method of production, the application of such a complex for obtaining a medicinal product for the treatment of cancer and medicinal product thus obtained.
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机译:络合物铂-二胺,一种生产方法,这种络合物在获得用于治疗癌症的药物中的应用以及由此获得的药物。
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摘要
This invention relates to novel platinum-diamine complexes having the formula: IMAGE (1) wherein R1 and R2 independently of each other may be selected from the group consisting of hydrogen, an alkyl group having 1-20 carbon atoms, a cycloalkyl group having from 3-7 carbon atoms in the ring, an aralkyl group, and an aryl group having 1-20 carbon atoms, whereas R1 and R2 together may form a cycloalkyl group having 3-7 carbon atoms in the ring and having the formula: IMAGE (1a) wherein N is 2 to 7 and wherein R3 and R4 independently of each other are selected from the group consisting of hydrogen, an alkyl group having 1-20 carbon atoms, an aryl group or an aralkyl group having 1-20 carbon atoms in the alkyl group and X is an anionic group, providing that when X is either chlorine or malonate, R1, R2, R3 and R4 are not each H; when X is chlorine and R1 and R2 are each H, R3 and R4 are not each methyl; when X is chlorine and R1 and R2 are each methyl, R3 and R4 are not each H, and when X is chlorine R1 is hydrogen and R2 is methyl and R3 and R4 are not each hydrogen.
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