1,4-DIHYDROPYRIDINE DERIVATIVES AND 1,4I-DIHYDROQUINOLINE DERIVATIVES RADIOACTIVATED BY 125I, THEIR PREPARATION AND THEIR APPLICATION TO DRUG TESTING

摘要

P A SIMPLE PROCESS FOR THE PREPARATION OF HIGHLY RADIOACTIVE DERIVATIVES, I-BRANDED, 1,4-DIHYDROPYRIDINE AND 1,4-DIHYDROQUINOLINE, OBTAINS SPECIFIC RADIOACTIVITY: ABOUT 2200-8800CIMMOLE. HIGH SENSITIVITY IS OBTAINED IN THE SCREENING OF MEDICINAL PRODUCTS USING THE RADIOACTIVE ASSAY OF RECEPTORS IN THE DETERMINATION OF THE PLASMATIC LEVEL OF 1,4-DIHYDROPYRIDINES, 1,4-DIHYDROQUINOLINS AND OTHER SUBSTANCES, WHICH INTERACT WITH THE RECEPTORS OF 1,4-DIHYDROPYRIDINE AND 1,4-DIHYDROQUINOLINE, SO THAT A SHORT-SHORT EXPOSURE PERIOD IS OBTAINED DURING THE AUTORADIOGRAPHIC REPRESENTATION OF RECEPTORS OF THESE SUBSTANCES. To this end, an amine derivative of a 1,4-dihydro-pyridine or 1,4-dihydroquinoline is reacted with an acylating reagent, which is radioactively labeled with I (2200-4400CIMMOLE), and the above-mentioned derivative is isolated. PAR I, WHICH HAS THE SPECIFIC RADIOACTIVITY OF THE ACYLANT REAGENT BY USUAL SEPARATION METHODS. / P