Topical compositions containing copper (II) complexes of 3,5- dioxo- pyrazolidine derivatives and methods of combatting inflammation with them

摘要

Novel copper (II) coordination complexes of 3,5-dioxo- pyrazolidine derivatives with dimethylsulphoxide, dimethylformamide, and 1,4-dioxan coordination ligands are described. The complexes are potent anti- inflammatory agents and are usually applied topically in non- aqueous solution, showing good dermal penetration and systemic absorption.