IMIDAZO(2,1-B)BENZOTHIAZOLE DERIVATIVE OR IMIDAZO(2,1-B) BENZOXAZOLE DERIVATIVE AND THEIR PREPARATION

摘要

NEW MATERIAL:The compound of formula I [R1 is lower alkyl, lower alkoxy- substituted aralkyl, or phenylureidoethyl of formula II (R4 is H or lower alkyl; R5 is halogen, lower alkyl, etc.; n is 0, 1 or 2); R2 is H, halogen, etc.; R3 is H, lower alkyl, lowr haloalkyl or phenyl; X is O or S; Y is H or halogen] and its salt. EXAMPLE:5-( 2-Hydroxy-3-phenylureidoethylaminopropoxy )-2-methylimidazo[ 2,1- b]benzothiazole. USE:A beta-receptor blocking agent. It suppresses the increase of pulse rate caused by isoproterenol and the relaxation of the histamine-induced constricted smooth muscle of the trachea. PREPARATION:The compound of formula I can be prepared by reacting the novel compound of formula III with the compound of formula R1NH in an inert solvent such as methanol, ethanol, etc.